Anti-ds-DNA IgA/IgG/IgM Screen ELISA
$399.00
Catalog
35-DSSHU-E01
The Anti-ds-DNA IgA/IgG/IgM Screen ELISA is a solid phase enzyme immunoassay with human recombinant double-stranded DNA (dsDNA) for the quantitative and qualitative detection of IgG, IgA, and IgM antibodies against dsDNA in human serum. Anti-dsDNA antibodies mainly recognize the phosphate units of DNA, thus these autoantibodies also bind single stranded DNA (ssDNA). To ensure correct quantitation of anti-dsDNA antibodies the antigen used in the kit has been proven to be free of contamination with ssDNA. The assay is a tool for the study of systemic lupus erythematosus (SLE).
Research Use Only. Not for Use in Diagnostic Procedures.
Minimum Order May be Required. Please call for details.
Species
Human
Regulatory Status
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available Worldwide
Range
3 - 300 U/mL
Sensitivity
1.0 U/mL
Sizes
96 Wells
Sample Types
Serum
Inc Time Hour
1
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
10
Detection
Colorimetric
Most individuals with SLE display IgG class antibodies against dsDNA. These autoantibodies are associated with lupus nephritis. In addition, approximately 30% of individuals with SLE develop IgA class anti-dsDNA antibodies. It has been suggested that the presence of these IgA class antidsDNA antibodies may define a certain subset of individuals with SLE. Studies demonstrated the association of this subclass with certain parameters of the disease activity, such as elevated erythrocyte sedimentation rate, or the consumption of complement component C3, as well as the clinical parameters of cutaneous vasculitis, acral necrosis, and erythema. No association was found for nephritis and arthritis.
