Anti-Phosphatidyl-Serine-IgG/IgM ELISA
$457.00
Catalog
35-SERHU-E01
The Anti-Phosphatidyl-Serine-Ig and IgM EIA is a solid phase enzyme immunoassay with highly purified phosphatidyl-serine plus native human ß2-glycoprotein I for the quantitative and qualitative detection of IgG and/ or IgM antibodies against phosphatidyl-serine in human serum. Research Use Only. Not for Use in Diagnostic Procedures.
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Species
Human
Regulatory Status
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available Worldwide
Range
3 - 300 U/mL
Sensitivity
1.0 U/mL
Sizes
96 Wells
Sample Types
Plasma, Serum
Inc Time Hour
1
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
10
Detection
Colorimetric
Antibodies against phosphatidyl-serine, an acidic phospholipid derived from glycerol, belong to the group of anti-phospholipid antibodies specific for phospholipids such as cardiolipin, phosphatidyl- inositol, -ethanolamin, -choline, sphingomyelin and phosphatidic acid.
Phospholipids are components of biological membranes.
Anti-phospholipid antibodies are frequently found in sera of subjects with systemic lupus erythematosus (SLE) and related diseases. The occurrence of anti-phospholipid antibodies in subjects with SLE and related diseases is typical for a secondary anti-phospholipid syndrome (APS). In contrast, antiphospholipid antibodies in people with no other autoimmune diseases characterize the primary APS.
Many studies have shown a correlation between these autoantibodies and an enhanced incidence of thrombosis, thrombocytopenia and habitual abortions (as a consequence of placental infarction). The exact mechanisms by which pathogenic anti-phospholipid antibodies induce thrombosis is not yet revealed fully.
