Anti-ss-DNA IgA/IgG/IgM Screen ELISA
$359.00
Catalog
35-SSSHU-E01
The Anti-ss-DNA Screen (IgA, IgG, IgM) ELISA is a solid phase enzyme immunoassay with human recombinant single stranded DNA (ssDNA) for the combined quantitative and qualitative detection of IgA/G/M antibodies against ssDNA in human serum. Antibodies against ssDNA mainly recognize its basic compound, which is masked inside the helical structure of native DNA. For Research Use Only. Not For Use In Diagnostic Procedures.
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Species
Human
Regulatory Status
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available in North America Only
Range
3 - 300 U/mL
Sensitivity
1.0 U/mL
Sizes
96 Wells
Sample Types
Serum
Inc Time Hour
1
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
10
Detection
Colorimetric
Antibodies binding to DNA belong to the group of anti-nuclear antibodies (ANA) which occur in several autoimmune diseases. Antibodies reacting with native double-stranded (ds) DNA are regarded as being specific for systemic lupus erythematosus (SLE) and appear in approximately 50-80% of these individuals. Antibodies against dsDNA are found during active phases of SLE, their serum concentration correlates with the severity of the disease.
Antibodies to single-stranded (ss) DNA are found with a frequency of up to 87% during acute phases and 43% during inactive phases in individuals with SLE. They are not specific for SLE as they may be found in other diseases like infectious mononucleosis (40%), autoimmune hepatitis (58%), acute myeloid leukemia (89%), acute lymphatic leukemia, chronic myeloid leukemia (60%) and juvenile rheumatoid arthritis (35-50%).
SLE-like symptoms may be induced by drugs. As anti-ssDNA antibodies are found in up to 50% of individuals with a drug-induced LE, the determination of antibodies against ssDNA is very helpful for this differentiation.
