The Mouse Haptoglobin ELISA is for the determination of Haptoglobin in Serum or Plasma of mice. Research Use Only. Not for Use in Diagnostic Procedures.
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available Worldwide
Range
7.81 - 125 ng/mL
Sensitivity
5 ng/mL
Sizes
96 Wells
Sample Types
Plasma, Serum
Inc Time Minute
35
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
5
Detection
Colorimetric
Acute phase proteins are plasma proteins which increase in concentration following infection,
inflammation or trauma. The first acute phase protein to be recognized was discovered in humans
by Tillet and Frances in 19301
. Haptoglobin is a heterogeneous plasma protein mostly
synthesized in by the liver. The haptoglobin monomer consist of two heavy chains, beta chains
(40 kD) and two light chains, alpha chains, alpha 1 (9 kD) and alpha 2 (16 kD) that are linked by
disulfide bonds. The three major haptoglobin types are; Hp1-1 which is monomeric (98kD), Hp1-
2 is polymeric at about 200 kD, and Hp2-2 at about 400 kD. The haptoglobin level in serum has
been shown to rise quickly following acute tissue damage within 24 to 48 hours and also falls very
rapidly once the stimulus is removed. Research indicates that haptoglobin levels are decreased
in hemolytic anemia. Haptoglobin has a high affinity for hemoglobin (Hb) and its function appears
to be to prevent loss of Hb in urine which would lead to loss of iron.
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