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Thrombotic mutations refer to mutations that affect the body’s blood clotting, or coagulation, system. Thrombotic mutations can be inherited (inherited thrombophilia) or acquired (acquired thrombophilia). These mutations can result in blood clot development leading to deep vein thrombosis and pulmonary embolism.

The Factor V Leiden mutation is one of the most prevalent mutations that leads to venous thromboembolism (VTE) or blood clots in the veins. The mutation is caused by a genetic defect of the F5 gene that controls the production of the protein coagulation factor 5. This defect can lead to a malfunction of the coagulation system allowing the development of abnormal blood clots.1

Thrombotic conditions are among the leading causes of death worldwide.2 Our thrombotic mutations PCR panel tests for the most prevalent mutations including:

• Factor II Prothrombrin
• Factor V Leiden
• Factor XIII V34L
• MTHFR C677T
• MTHFR A1298C
• PAI-1 Genotyping

Featured: GeneProof Factor V Leiden PCR Kit

Request a Quote For Research Use Only in North America. Not for use in diagnostic procedures.

• Up to 6 different tests from one sample in a single run

• Full automation reduces staff and organizational requirements

• All PCR kits are easily combined into one workflow

• No additional pipetting of Ready-to-Use Master Mix necessary

• Service guaranteed within 24 hours

• Result consultation

• Laboratory workflow analysis

• Training program

References

1. https://medlineplus.gov/genetics/condition/factor-v-leiden-thrombophilia/
2. https://my.clevelandclinic.org/health/diseases/22242-thrombosis 

Full Thrombotic Mutations PCR Panel

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