Iron Regulation and Homeostasis: Kits to Study Regulatory Proteins
Iron Homeostasis
Iron is a trace element required for several critical cellular processes. Too little iron (anemia) or too much iron (iron overload) can be harmful. While there is no known mechanism for the controlled excretion of excess iron, a handful of regulatory proteins control the absorption, transport, and storage of iron to maintain homeostasis.1,2 ALPCO offers several kits for the study of these important regulatory proteins.
Ceruloplasmin is a copper transport protein involved in iron metabolism. It oxidizes toxic ferrous iron to its nontoxic ferrous form.
Ceruloplasmin ELISA 41-CERHU-E01 For the quantitative determination of Ceruloplasmin in human plasma and serum samples.
Transferrin is the major iron transport protein in plasma. Transferrin ELISA (41-TRAHU-E01) For the measurement of transferrin in human serum and plasma samples. Mouse Transferrin ELISA (41-TRAMS-E01) For the quantitative determination of transferrin in mouse serum and plasma. Rat Transferrin ELISA (41-TRART-E01) For the determination of transferrin in serum and plasma of rats.
Ferritin is a cellular iron storage protein that sequesters potentially harmful, reactive iron for storage in its unreactive Fe3+ form. Ferritin (ELISA 11-FERHU-E01) A highly sensitive immunoassay for the quantitative determination of ferritin in serum samples. Mouse Ferritin (ELISA 41-FERMS-E01) For the quantitative determination of ferritin in mouse serum and plasma. Rat Ferritin ELISA (41-FERRT-E01) For the determination of ferritin in serum and plasma of rats.
Lipocalin-2 (NGAL) is an iron regulatory protein that plays a protective role in infection and inflammation.
Lipocalin-2 (NGAL) ELISA (54-036) For the determination of NGAL (neutrophil gelatinase-associated lipocalin) in human serum, plasma, tissue extracts or culture media. Mouse Lipocalin-2 (NGAL) ELISA (41-NGALMS-E01) For the quantitative determination of Lipocalin-2/NGAL in mouse plasma, serum, and urine samples.
References:
1. Daniel F. Wallace (2016). The regulation of iron absorption and homeostasis. Clin Biochem Rev 37 (2)
2. Mackenzie, E.L., et al. (2008). Intracellular iron transport and storage: from molecular mechanisms to health implications
