Tips & Tricks
The Enzyme-Linked Immunosorbent Assay (ELISA) is a proven sensitive method for detecting and quantifying specific biomarkers in a wide range of clinical and research samples. The accuracy and precision of ELISAs can be affected by many factors, including pipetting, washing, and sample-handling techn...
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New: Calprotectin Immunoturbidimetric Assay will take your testing to the next level. Learn more.Supporting your work with life science and clinical testing productsVIEW ALL LIFE SCIENCE PRODUCTSVIEW ALL CLINICAL DIAGNOSTIC PRODUCTS
Investigating Immunogenicity of IBD Biologics
Biologics have been commonly prescribed as therapies for inflammatory bowel disease (IBD) since the late 1990s. However, research demonstrates that not all individuals respond to the first biologic taken and many lose response over time1. As a result, there is a great need to explore the immunogenic...
A Guide to STELLUX® Chemiluminscence ELISAs: An Infographic
Today, multiple immunoassay platforms exist, providing scientists and clinicians with the means to measure a variety of biomarkers1,2,3. However, research indicates some immunoassay platforms have limitations that can inhibit progress in the laboratory4,5,6. In an effort to provide researchers with ...
A Comparison of Colorimetric and Chemiluminescence ELISAs
Are you curious about chemiluminescence ELISAs, but not exactly sure what they are, or how to use them? Our video A Comparison of Colorimetric and Chemiluminescence ELISAs discusses how similar these two types of assays are, and how they can enhance your lab testing.
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12 ELISA Tips and Tricks: An Expert’s Guide to Improve Your Technique
The Enzyme-Linked Immunosorbent Assay (ELISA) is a proven sensitive method for detecting and quantifying specific biomarkers in a wide range of clinical and research samples. The accuracy and precision of ELISAs can be affected by many factors, including pipetting, washing, and sample-handling techn...
ALPCO Releases STELLUX® Chemiluminescent Human Intact Proinsulin ELISA
ALPCO announced in a press release on February 18, 2014 that the company has launched their new STELLUX® Chemiluminescent Human Intact Proinsulin ELISA, the latest assay to be launched in the company’s STELLUX® Chemiluminescent product line. The new Human Intact Proinsulin ELISA features a broad dyn...
ALPCO Releases New Chemiluminescent Human C-peptide ELISA
ALPCO announced the launch of its new STELLUX® Chemiluminescent Human C-peptide ELISA on December 5, 2014. This highly characterized assay measures C-peptide requiring only 50 µL of human serum, plasma or cell culture supernatant. The ELISA exhibits greater sensitivity and a broader dynamic range co...
Complement System Solutions for Drug Development and Clinical Research
Datasheet: Complement System Immunoassays
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The complement system is essential to innate immunity which protects from chronic, autoimmune, and infectious disease. There are three distinct pathways of complement activation: classical, lectin/MBL, and alternative. Each leads...
Bone Metabolism: The Cycle of Bone Growth and Resorption
Bone metabolism is a continual cycle of bone growth and resorption that is carefully orchestrated by the dynamic relationship between osteoclasts, osteoblasts and an array of hormonal and regulatory influences. The relative levels of these signaling molecules dictate whether healthy, balanced bo...
Toxicology
Drug-Induced Organ Injury
Toxicological side effects are a common obstacle in drug development pipelines and often manifest in site-specific damage to vital organs, including the liver, kidney and heart. Estimates of compound attrition from failure to meet safety endpoints are as high as 45% in pre...
How Should We Define Vitamin D Deficiency?
Date: July 21, 2015
Author: Bethany Bell, PhD; Senior Product Manager at ALPCO
Dr. Anders Berg presented at the Northeast Laboratory Conference in October 2014 regarding a much debated topic: vitamin D deficiency and how this should be defined. Dr. Berg referenced over one thousand studies, re...
Understanding the Role of Energy Homeostasis in Diabetes
Introduction
The prevalence of diabetes and obesity has been on the rise for several decades and research has demonstrated that other parts of the body, including the cardiovascular system and kidneys, can be affected by diabetes. The key to understanding the relationship between diabetes and the...
ALPCO and Cisbio US, Inc. Announce Sales and Distribution Agreement
Date: July 1, 2015
ALPCO is pleased to announce a strategic account sales and distribution agreement with Cisbio US, Inc. Cisbio will now have exclusive access to ALPCO’s high quality STELLUX® Chemiluminescence and colorimetric Diabetes and Obesity assay portfolio in order to provide these produc...
ALPCO Releases a New Broad Range Periostin ELISA
ALPCO is now offering a new broad range Periostin ELISA that has been optimized to detect all known splicing forms of human periostin. The Periostin ELISA is highly characterized with a full validation package, and offers great reproducibility and precision. Not only are all standards and controls i...
De-escalating Inflammatory Bowel Disease Therapies
Date: June 21, 2016
Author: Andrea Tarbet, Product Marketing Associate at ALPCO
Several therapies exist to help treat inflammatory bowel disease (IBD) and improve patient quality of life. However, a growing number of gastroenterologists and patients have been choosing to stop these therapies -...
BTK Inhibitors as Cancer Drug Treatments
Date: July 26, 2016
Author: Andrea Tarbet, Product Marketing Associate at ALPCO
Over the past several years, the drug arsenal to combat B cell cancers has gained a mighty weapon: Bruton’s tyrosine kinase (BTK) inhibitors. The origins of using BTK inhibitors as cancer drug treatments actually b...
Class IA PI3K Inhibitor Cancer Therapies
Date: August 16, 2016
Author: Andrea Tarbet, Product Marketing Associate at ALPCO
Bruton’s tyrosine kinase (BTK) inhibitors are not the only kinase inhibitors to enter the fight against B cell cancers. Since there are numerous subtypes of Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL), p...
PI3K Delta Signaling in Rheumatoid Arthritis
Date: September 6, 2016
Author: Andrea Tarbet, Product Marketing Associate at ALPCO
Signaling pathways dictate the differentiation, activation, and functions of immune cells. Even the slightest problem in one cell signaling pathway can transform the immune system and turn it against the body,...