Serum Amyloid A ELISA (SAA ELISA)

SAA has a number of immunomodulatory roles, it can induce chemotaxis and adhesion molecule expression, has cytokine-like properties and can promote the upregulation of metalloproteinases. It enhances the binding of high-density lipoprotein to macrophages and thus assists in the delivery of lipids to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease processes. In addition, SAA is involved in cholesterol transport and metabolism SAA is an acute phase reactant and has been found to be elevated in many inflammatory states. The best known indicator of inflammation is C-reactive protein (CRP). However, SAA rises earlier and more sharply than CRP. In contrast to CRP, SAA presents the same trend in viral as well as bacterial infections. SAA increases dramatically during acute inflammation and may reach levels 1000-fold higher than normal. Furthermore, SAA is an early indicator for transplant rejection, a possible marker for tumor activity and clinically useful in bacterial and viral infection. Elevated levels of SAA over time predispose to secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissues and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid arthritis.