Anti-ds-DNA-A ELISA
$399.00
Catalog
35-DSAHU-E01
The Anti-ds-DNA-A ELISA is a solid phase enzyme immunoassay with human recombinant double stranded DNA (dsDNA) for the quantitative and qualitative detection of IgA antibodies against dsDNA in human serum. Anti-dsDNA antibodies mainly recognize the phosphate units of DNA, thus these autoantibodies also bind single stranded DNA (ssDNA). To ensure correct quantitation of anti-dsDNA antibodies the antigen used in the kit has been proven to be free of contamination with ssDNA. The Anti-ds-DNA-A ELISA is a tool for the study of systemic lupus erythematosus (SLE).
Research Use Only. Not for Use in Diagnostic Procedures.
Minimum Order Required. Please call for details.
Species
Human
Regulatory Status
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available Worldwide
Range
3 - 300 U/mL
Sensitivity
1.0 U/mL
Sizes
96 Wells
Sample Types
Serum
Inc Time Hour
1
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
10
Detection
Colorimetric
Antibodies binding to DNA belong to the group of anti-nuclear antibodies (ANA) that have been observed in several autoimmune diseases. Antibodies reacting with native double-stranded (ds) DNA are regarded as being specific for systemic lupus erythematosus (SLE) and have been observed in approximately 50-80% of individuals with SLE.
Research has shown approximately 30% SLE individuals develop IgA class anti-dsDNA antibodies. There have been suggestions that the presence of these IgA class anti-dsDNA antibodies may define a certain subset of SLE individuals. Indeed, studies have demonstrated the association of this subclass with certain parameters of the disease activity, such as elevated erythrocyte sedimentation rate, or the consumption of complement component C3.
