SM is a solid phase enzyme immunoassay with highly purified native Smith antigen (Sm) from human eukaryotic cells (HeLa) for the quantitative and qualitative detection of antibodies against Sm in human serum. Anti-Sm antibodies recognize specific conformational epitopes only accessible on native human Sm.
Research Use Only. Not for Use in Diagnostic Procedures.
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available in North America Only
Range
3 - 300 U/mL
Sensitivity
1.0 U/mL
Sizes
96 Wells
Sample Types
Serum
Inc Time Hour
1
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
10
Detection
Colorimetric
The term “Smith antigen“ summarizes core proteins of the U1-snRNP complex. The U1snRNP complex is a part of the splicosomal complex, that facilitates the processing of pre-mRNA to mature mRNA in the nucleus. It is a small nuclear ribonucleoprotein particle composed of uridine-rich (thus U) small nuclear RNA and a set of proteins: the 70 kDa U1specific protein plus proteins A and C (all formerly summarized as RNPs) and the Sm antigen which comprises eight proteins (B,/B`, D1, D2, D3, E, F, and G). Because of its protein components Sm and RNPs the complex has been often named Sm/RNP complex.
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