The IGFBP-2 ELISA is for the quantitative determination of IGFBP-2 in human serum, plasma, saliva, CSF, amniotic fluid, breast milk, and cell culture medium. For Research Use only. Not For In Vitro Diagnostic Use.
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available Worldwide
Range
2 - 80 ng/mL
Sensitivity
0.2 ng/mL
Sizes
96 Wells
Sample Types
Breast Milk, Cell Culture, EDTA Plasma, Plasma, Saliva, Serum
Inc Time Hour
1
Inc Time Minute
45
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
15
Detection
Colorimetric
Insulin-like growth factors (IGFs) regulate the proliferation, differentation, apoptose, cell adhesion and metabolism in various tissues and cell types. The IGF-I, which is produced mainly in liver under the influence of growth hormone (GH), regulates as hormone the linear growth of the bones and the process of sexual maturity, while IGF-II is mainly a growth factor of fetal tissue. The biological actions of IGF over the IGF-Type-I receptor are modulated variably through the IGF binding proteins (IGFBP-1 to-6). IGFBP-2 is, after IGFBP-3, the second most frequent IGFBP in the human blood. IGFs, especially tumor typical pro-IGFforms and hormones regulate the expression of IGFBP-2, GH effect is thereby inhibiting. At cellular level IGFBP-2 seems to stimulate the proliferation and dissemination of solid tumors via an IGF-independent mechanism.
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