The MRP8/14 ELISA is intended for the quantitative determination of S100A8/A9 in human serum, plasma, stool, urine and cell culture. Research Use Only. Not for Use in Diagnostic Procedures.
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available in USA Only
Range
0.25 - 15.6 ng/mL
Sensitivity
0.25 ng/mL
Sizes
96 Wells
Sample Types
Cell Culture, Plasma, Serum, Stool, Urine
Inc Time Hour
3
Inc Time Minute
15
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
100
Detection
Colorimetric
Calprotectin is a calcium-binding protein secreted predominantly by neutrophils and monocytes. The heterocomplex consists of the two proteins, S100A8 (calgranulin A) and S100A9 (calgranulin B), also designated as MRP8 and MRP14, respectively.
Expression of S100A8 and S100A9 in epithelial tissues was first described in context with squamous epithelia and with murine and human wound repair. More recently, an association of S100 protein expression with adenocarcinomas in humans has
emerged. The genes S100A8 and S100A9 are located in a gene cluster on chromosome 1q21, a region in which several rearrangements that occur during tumor development have been observed.
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