Neuron Specific Enolase ELISA (NSE ELISA)
$601.00
Catalog
43-NSEHU-E01
The Neuron Specific Enolase ELISA (NSE ELISA) is intended for the quantitative determination of human neuron specific enolase (NSE) levels in serum samples. The Neuron Specific Enolase ELISA (NSE ELISA) might be used as an aid in researching neuronendocrine differentiated tumors such as small cell lung cancer and neuroblastoma, melanoma, seminoma; and with injury of the central nervous system such as traumatic brain injury (TBI).
Research Use Only. Not for Use in Diagnostic Procedures.
Species
Human
Regulatory Status
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available Worldwide
Range
5 - 178 ng/mL
Sensitivity
1.2 ng/mL
Sizes
96 Wells
Sample Types
Serum
Inc Time Hour
1
Inc Time Minute
10
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
10
Detection
Colorimetric
The glycolytic enzyme enolase (2-phospho-D-glycerate hydro-lyase) exists as several dimeric
isoenzymes (αα, αβ, ββ and γγ) composed of three distinct subunits: α, β, and γ. Three isoenzymes are found in the human brain: αα, αβ, and γγ. The heterologous αγ-isoenzyme and the
homologous γγ-enolase isoenzymes are known as neuron-specific enolase (NSE) as these
isoenzymes initially were detected in neurons and neuroendocrine cells. This assay detects both
the αγ and the γγ forms by using monoclonal antibodies specific to the γ-subunit of the enzyme.
Research demonstrates that NSE may be a valuable tumor biomarker of neuroendocrine origin,
particularly in small cell lung cancer and in neuroblastoma.
