Pre-Albumin ELISA
$303.00
Catalog
30-6331
This assay is an ELISA intended for the quantitative determination of prealbumin (transthyretin) in serum, plasma, urine and stool. For research use only. Not for use in diagnostic procedures.
Species
Human
Regulatory Status
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available in North America Only
Range
1.6 - 100 ng/mL
Sensitivity
3.0 ng/mL
Sizes
96 Wells
Sample Types
Plasma, Serum, Stool
Inc Time Hour
2
Inc Time Minute
15
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
100
Detection
Colorimetric
Prealbumin (transthyretin) is a transport protein secreted in the liver, brain and retina. It transports thyroxin (T4
) and retinol binding protein in serum and cerebrospinal
fluid. Its names are derived from its function (transports thyroxin and retinol) and the
fact that it runs in front of albumin (prealbumin) in electrophoresis gels.
Prealbumin (transthyretin) is a 55kDa homotetramer with a dimer of dimers quaternary structure. Each monomer is a 127-residue polypeptide rich in beta sheets. Association of two monomers forms a dimer, two dimers produce the homotetrameric
structure and create the two thyroxine binding sites per tetramer.
Transthyretin is reduced in inflammatory reactions and is therefor an acute-phase
protein. A mutation in the transthyretin gene can result in a chronically lowered transthyretin level in the blood, leading to amyloidosis. Transthyretin is the protein with
the highest proportion of essential amino acids and has a rather short biological halflife of 1–2 days.
